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Toutes les publications de l'ENAC en direct.
All ENAC publications.

[hal-01814332] MNPR: A Framework for Real-Time Expressive Non-Photorealistic Rendering of 3D Computer Graphics

Publications ENAC - Mercredi, 20 juin 2018 - 13:56:12
We propose a framework for expressive non-photorealistic rendering of 3D computer graphics: MNPR. Our work focuses on enabling stylization pipelines with a wide range of control, thereby covering the interaction spectrum with real-time feedback. In addition, we introduce control semantics that allow cross-stylistic art-direction, which is demonstrated through our implemented watercolor, oil and charcoal stylizations. Our generalized control semantics and their style-specific mappings are designed to be extrapolated to other styles, by adhering to the same control scheme. We then share our implementation details by breaking down our framework and elaborating on its inner...

[hal-01819273] Systematic assessment of multi-gene predictors of pan-cancer cell line sensitivity to drugs exploiting gene expression data

Publications ENAC - Mercredi, 20 juin 2018 - 13:56:11
Background: Selected gene mutations are routinely used to guide the selection of cancer drugs for a given patient tumour. Large pharmacogenomic data sets, such as those by Genomics of Drug Sensitivity in Cancer (GDSC) consortium, were introduced to discover more of these single-gene markers of drug sensitivity. Very recently, machine learning regression has been used to investigate how well cancer cell line sensitivity to drugs is predicted depending on the type of molecular profile. The latter has revealed that gene expression data is the most predictive profile in the pan-cancer setting. However, no study to date has exploited GDSC data to systematically compare the...

[hal-01771520] Manipulating the Relaxation of Quasi- D Dysprosium Compounds through Alternation of the O-Donor Ligands

Publications ENAC - Mercredi, 20 juin 2018 - 13:48:33
Three mononuclear Dy complexes with the same auxiliary ligand Lz (2,4-diamino-6-pyridyl-1,3,5-triazine), [Dy(TTA)Lz] (1Dy) (TTA = 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedionate), [Dy(acac)Lz]·CHOH·0.5HO (2Dy) (acac = acetylacetonate), and [Dy(MQ)Lz]Br·CHOH (3Dy) (HMQ = 2-methyl-8-quinolinol), have been synthesized through alteration of the ligands containing O donors. In all three complexes, the Dy ions are eight-coordinate and submitted to pseudo- D symmetry in the first coordination sphere. It is noteworthy that the TTA ligands in 1Dy are easily substituted by other bidentate capping ligands with O donors, leading to distinct magnetic properties, which were studied...

[hal-01807088] Rhenium and Manganese Complexes Bearing Amino-Bis(phosphinite) Ligands Synthesis, Characterization, and Catalytic Activity in Hydrogenation of Ketones

Publications ENAC - Mercredi, 20 juin 2018 - 13:40:36
A series of rhenium and manganese complexes supported by easily accessible and easily tunable amino-bisphosphinite ligands was prepared and characterized by NMR and IR spectroscopy, HR mass spectrometry, elemental analysis, and X-ray diffraction studies. These complexes have been tested in the hydrogenation of ketones. Notably, one of the rhenium complexes, bearing an NH moiety, proved significantly more active than the rest of the series. The reaction proceeds well at 120 degrees C, under SO bar of H-2, in the presence of 0.5 mol % of catalyst and 1 mol % of tBuOK. Interestingly, activation of the precatalyst could be followed stepwise by NMR and a rhenium hydride was...

[inserm-01819245] Adult female acne treated with spironolactone: a retrospective data review of 70 cases

Publications ENAC - Mercredi, 20 juin 2018 - 13:26:25
The prevalence of acne in the adult population is increasing, particularly in women. Spironolactone regulates sebaceous gland activity by blocking androgen receptor. To evaluate retrospectively the efficacy of spironolactone in women with acne. Data from 70 women of at least 20 years, treated for their acne between 2010 and 2015 with low-dose spironolactone (≤150 mg/day), were analysed. Remission was defined by the number of retentional lesions inferior or equal to five and inflammatory lesions inferior or equal to two on the face. Variables influencing the response were studied using the Cox model. The mean age was 31.3 years; 39 (56%) women had prior courses of...

[hal-01819040] The role of the Hardy type inequalities in the theory of function spaces

Publications ENAC - Mercredi, 20 juin 2018 - 10:53:12
We illustrate the crucial importance of the Hardy type inequalities in the study of function spaces, especially of fractional regularity. Immediate applications include Sobolev and Morrey type embeddings, and properties of the superposition operator $f\mapsto \Phi\circ f$. Another fundamental consequence is the trace theory of weighted Sobolev spaces. In turn, weighted Sobolev spaces are useful in the regularity theory of the superposition operators. More involved applications, that we present in the final section, are related to Sobolev spaces of maps with values into manifolds.

[hal-01819013] Two-dimensional macroscopic model for large scale traffic networks

Publications ENAC - Mercredi, 20 juin 2018 - 10:47:08
In this article we introduce a new traffic flow model for a dense urban area. We consider a two-dimensional conservation law in which the velocity magnitude is given by the fundamental diagram and the velocity direction is constructed following the network geometry. We validate the model using synthetic data from Aimsun and propose a reconstruction technique to recover the 2D density from the data of individual vehicles. A comparison between the model and the data is shown.

[hal-01578728] Existence of Lipschitz continuous Lyapunov functions strict outside the strong chain recurrent set

Publications ENAC - Mercredi, 20 juin 2018 - 10:44:56
The aim of this paper is to study in detail the relations between strong chain recurrence for flows and Lyapunov functions. For a continuous flow on a compact metric space, uniformly Lipschitz continuous on the compact subsets of the time, we first make explicit a Lipschitz continuous Lyapunov function strict –that is strictly decreasing– outside the strong chain recurrent set of the flow. This construction extends to flows some recent advances of Fathi and Pageault in the case of homeomorphisms; moreover, it improves Conley's result about the existence of a continuous Lyapunov function strictly decreasing outside the chain recurrent set of a continuous flow. We then...

[tel-01819085] Etude du peptidome du cervelet de rat au cours du développement et identification des effets neurotrophiques de la nociceptine dans la mise en place des neurones en grain.

Publications ENAC - Mercredi, 20 juin 2018 - 03:23:07
Le cervelet est une structure cérébrale impliquée dans de multiples fonctions motrices mais aussi cognitives et dont le développement postnatal est sous le contrôle de divers types de facteurs dont les neuropeptides. Les peptides capables d’agir sur le développement du cortex cérébelleux présentent généralement un profil d’expression particulier, avec chez le rongeur un pic d’expression au cours des 2 premières semaines postnatales. L’objectif de cette étude était d’identifier d’autres peptides présentant ce même type d’expression et de caractériser leurs potentiels effets au cours du développement du cortex cérébelleux, et plus particulièrement dans la mise en place des...

[tel-01819084] Adaptive optics for fluorescence correlation spectroscopy

Publications ENAC - Mercredi, 20 juin 2018 - 03:01:19
This research project combines two complementary aspects: the development of an assembly incorporating an Adaptive Optics microscope system and the study of cancerous masses (multicellular spheroids) under mechanical pressure.These two axes are mutually beneficial since the implementation of the adaptive optics will enable imaging and physical measurements in spheroids; On the other hand, the study of spheroids will characterize the aberrations induced by this type of samples and understand the requirements of the adaptive optics system imposed by the observation of these samples as well as the limits of optical microscopy in biological tissues.
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